Prior work has extensively studied the latent space structure of GANs for unconditional image synthesis, enabling global editing of generated images by the unsupervised discovery of interpretable latent directions. However, the discovery of latent directions for conditional GANs for semantic image synthesis (SIS) has remained unexplored. In this work, we specifically focus on addressing this gap. We propose a novel optimization method for finding spatially disentangled class-specific directions in the latent space of pretrained SIS models. We show that the latent directions found by our method can effectively control the local appearance of semantic classes, e.g., changing their internal structure, texture or color independently from each other. Visual inspection and quantitative evaluation of the discovered GAN controls on various datasets demonstrate that our method discovers a diverse set of unique and semantically meaningful latent directions for class-specific edits.

与生成对抗网络（GAN）的图像和分割掩模的联合合成有望减少用像素通过像素注释收集图像数据所需的精力。但是，要学习高保真图像掩码合成，现有的GAN方法首先需要一个需要大量图像数据的预训练阶段，这限制了其在受限图像域中的利用。在这项工作中，我们迈出了一步，以减少此限制，从而引入了单次图像掩码合成的任务。我们旨在仅给出一个单个标记的示例，生成各种图像及其分割面具，并假设与以前的模型相反，则无法访问任何预训练数据。为此，我们受到单图像gan的最新体系结构发展的启发，我们介绍了OSMIS模型，该模型可以合成分割掩模，这些掩模与单次镜头中生成的图像完全一致。除了实现产生的口罩的高保真度外，OSMIS在图像合成质量和多样性中的最先进的单图像模型优于最先进的单位图。此外，尽管没有使用任何其他数据，OSMIS还是表现出令人印象深刻的能力，可以作为一击细分应用程序的有用数据增强的来源，提供了与标准数据增强技术相辅相成的性能提高。代码可从https://github.com/ boschresearch/One-shot-synthesis获得

Semantic labelling and instance segmentation are two tasks that require particularly costly annotations. Starting from weak supervision in the form of bounding box detection annotations, we propose a new approach that does not require modification of the segmentation training procedure. We show that when carefully designing the input labels from given bounding boxes, even a single round of training is enough to improve over previously reported weakly supervised results. Overall, our weak supervision approach reaches ∼ 95% of the quality of the fully supervised model, both for semantic labelling and instance segmentation.

Novel topological spin textures, such as magnetic skyrmions, benefit from their inherent stability, acting as the ground state in several magnetic systems. In the current study of atomic monolayer magnetic materials, reasonable initial guesses are still needed to search for those magnetic patterns. This situation underlines the need to develop a more effective way to identify the ground states. To solve this problem, in this work, we propose a genetic-tunneling-driven variance-controlled optimization approach, which combines a local energy minimizer back-end and a metaheuristic global searching front-end. This algorithm is an effective optimization solution for searching for magnetic ground states at extremely low temperatures and is also robust for finding low-energy degenerated states at finite temperatures. We demonstrate here the success of this method in searching for magnetic ground states of 2D monolayer systems with both artificial and calculated interactions from density functional theory. It is also worth noting that the inherent concurrent property of this algorithm can significantly decrease the execution time. In conclusion, our proposed method builds a useful tool for low-dimensional magnetic system energy optimization.

The release of ChatGPT, a language model capable of generating text that appears human-like and authentic, has gained significant attention beyond the research community. We expect that the convincing performance of ChatGPT incentivizes users to apply it to a variety of downstream tasks, including prompting the model to simplify their own medical reports. To investigate this phenomenon, we conducted an exploratory case study. In a questionnaire, we asked 15 radiologists to assess the quality of radiology reports simplified by ChatGPT. Most radiologists agreed that the simplified reports were factually correct, complete, and not potentially harmful to the patient. Nevertheless, instances of incorrect statements, missed key medical findings, and potentially harmful passages were reported. While further studies are needed, the initial insights of this study indicate a great potential in using large language models like ChatGPT to improve patient-centered care in radiology and other medical domains.

Efficient surrogate modelling is a key requirement for uncertainty quantification in data-driven scenarios. In this work, a novel approach of using Sparse Random Features for surrogate modelling in combination with self-supervised dimensionality reduction is described. The method is compared to other methods on synthetic and real data obtained from crashworthiness analyses. The results show a superiority of the here described approach over state of the art surrogate modelling techniques, Polynomial Chaos Expansions and Neural Networks.

Purpose: Tracking the 3D motion of the surgical tool and the patient anatomy is a fundamental requirement for computer-assisted skull-base surgery. The estimated motion can be used both for intra-operative guidance and for downstream skill analysis. Recovering such motion solely from surgical videos is desirable, as it is compliant with current clinical workflows and instrumentation. Methods: We present Tracker of Anatomy and Tool (TAToo). TAToo jointly tracks the rigid 3D motion of patient skull and surgical drill from stereo microscopic videos. TAToo estimates motion via an iterative optimization process in an end-to-end differentiable form. For robust tracking performance, TAToo adopts a probabilistic formulation and enforces geometric constraints on the object level. Results: We validate TAToo on both simulation data, where ground truth motion is available, as well as on anthropomorphic phantom data, where optical tracking provides a strong baseline. We report sub-millimeter and millimeter inter-frame tracking accuracy for skull and drill, respectively, with rotation errors below 1{\deg}. We further illustrate how TAToo may be used in a surgical navigation setting. Conclusion: We present TAToo, which simultaneously tracks the surgical tool and the patient anatomy in skull-base surgery. TAToo directly predicts the motion from surgical videos, without the need of any markers. Our results show that the performance of TAToo compares favorably to competing approaches. Future work will include fine-tuning of our depth network to reach a 1 mm clinical accuracy goal desired for surgical applications in the skull base.

Selecting the number of topics in LDA models is considered to be a difficult task, for which alternative approaches have been proposed. The performance of the recently developed singular Bayesian information criterion (sBIC) is evaluated and compared to the performance of alternative model selection criteria. The sBIC is a generalization of the standard BIC that can be implemented to singular statistical models. The comparison is based on Monte Carlo simulations and carried out for several alternative settings, varying with respect to the number of topics, the number of documents and the size of documents in the corpora. Performance is measured using different criteria which take into account the correct number of topics, but also whether the relevant topics from the DGPs are identified. Practical recommendations for LDA model selection in applications are derived.

Previous work has shown the potential of deep learning to predict renal obstruction using kidney ultrasound images. However, these image-based classifiers have been trained with the goal of single-visit inference in mind. We compare methods from video action recognition (i.e. convolutional pooling, LSTM, TSM) to adapt single-visit convolutional models to handle multiple visit inference. We demonstrate that incorporating images from a patient's past hospital visits provides only a small benefit for the prediction of obstructive hydronephrosis. Therefore, inclusion of prior ultrasounds is beneficial, but prediction based on the latest ultrasound is sufficient for patient risk stratification.

Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason grade is assigned based on tumor architecture on Hematoxylin and Eosin (H&E) stained whole slide images (WSI) by the pathologists. This process is time-consuming and has known interobserver variability. In the past few years, deep learning algorithms have been used to analyze histopathology images, delivering promising results for grading prostate cancer. However, most of the algorithms rely on the fully annotated datasets which are expensive to generate. In this work, we proposed a novel weakly-supervised algorithm to classify prostate cancer grades. The proposed algorithm consists of three steps: (1) extracting discriminative areas in a histopathology image by employing the Multiple Instance Learning (MIL) algorithm based on Transformers, (2) representing the image by constructing a graph using the discriminative patches, and (3) classifying the image into its Gleason grades by developing a Graph Convolutional Neural Network (GCN) based on the gated attention mechanism. We evaluated our algorithm using publicly available datasets, including TCGAPRAD, PANDA, and Gleason 2019 challenge datasets. We also cross validated the algorithm on an independent dataset. Results show that the proposed model achieved state-of-the-art performance in the Gleason grading task in terms of accuracy, F1 score, and cohen-kappa. The code is available at https://github.com/NabaviLab/Prostate-Cancer.